耗材描述
α-Carotene
产品活性:α-Carotene 是维生素 A 的前体,用作抗转移剂或用作抗癌药的佐剂。α-Carotene 是从橙黄色和深绿色蔬菜中分离出来的。
产品来源: https://www.medchemexpress.cn/α-carotene.html
研究领域:Others
作用靶点:Others
来源:植物 | 菊科 | Decachaeta ovatifolia (DC.) R.M.King & H.Rob. | 植物 | 伞形科
结构分类:萜类 | 其他萜类 | 结构分类
In Vitro: α-Carotene (0.5-2.5 μM; 24 hours) significantly increases protein expression of TIMP-1 and TIMP-2 in a concentration-dependent manner in LLC cells. AC (0.5-2.5 μM) significantly increases PAI-1 protein expression. α-Carotene (2.5 μM) also significantly inhibits integrin β1-mediated phosphorylation of focal adhesion kinase (FAK) which then decreased the phosphorylation of MAPK family.
α-Carotene (0.5, 1, 2.5 μM; 48 hours) significantly and concentration-dependently inhibits invasion of LLC during 48 h of incubation.
α-Carotene (0.5, 1, 2.5 μM; 24 hours) significantly decreases activities of MMP-9, -2 and uPA in concentration-dependent manner in LLC cells.
α-Carotene (2, 5, 10 μM; 7 days) inhibits the proliferation of the human neuroblastoma cell line GOTO in a dose- and time-dependent manner. α-Carotene (5 μM; 48 hours) halts the cell cycle at the G0/G1 phase concomitantly with a reduction in the mRNA expression of the protooncogene N-Myc.
In Vivo: α-Carotene (5 mg/kg; oral; twice a week; for additional 3 weeks) alone significantly decreases lung metastasis without affecting primary tumor growth.
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