耗材描述
AFMK
产品活性:AFMK 是褪黑激素的一种抗氧化代谢物,可减弱 X 射线诱导的小鼠 DNA、蛋白质和脂质氧化损伤。AFMK 是效果稍低的一种清洁剂,在生理 pH 值下的 pKa 为 8.7。具有抗氧化活性。AFMK 可通过调节细胞凋亡途径提高 Gemcitabine 在 PANC-1 细胞中的抗肿瘤作用。
产品来源: https://www.medchemexpress.cn/afmk.html
研究领域:Metabolic Enzyme/Protease
作用靶点:Endogenous Metabolite
结构分类:生物碱 | 其他类生物碱 | 结构分类
In Vitro: AFMK is one of the metabolites of melatonin and can be formed by both enzymatic or pseudoenzymatic and nonenzymatic metabolic pathways.
AFMK pretreatment significantly inhibits DNA damage. AFMK shows a very high level of in vitro hydroxyl radical scavenging potential which was measured by an electron spin resonance (ESR) study. IC50 values resulting from ESR analysis was 338.08 nM. AFMK, a melatonin metabolite, is a sparingly investigated biogenic amine.
AFMK administered to PANC-1 in combination with Gemcitabine inhibits the production of HSP70 and cIAP-2 as compared to the results obtained with Gemcitabine alone.
In Vivo: AFMK is a potent antioxidant in vivo. AFMK significantly reverses radiation-induced decline in the total antioxidant capacity of plasma in mice.
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