耗材描述
Indolelactic acid
产品活性:Indolelactic acid (Indole-3-lactic acid) 是一种 Azotobacter vinelandii 培养过程中产生的的色氨酸 (Trp) 分解代谢物。Indolelactic acid 具有抗炎和潜在的抗病毒活性。
产品来源: https://www.medchemexpress.cn/Indolelactic_acid.html
研究领域:Metabolic Enzyme/Protease
作用靶点:Endogenous Metabolite
结构分类:酮、醛、酸 | 结构分类
In Vitro: Indolelactic acid (1 mM, 5 days) upregulates CXCR3, granzyme B, and immunoregulatory galectin-1 in Th2 cells.
Indolelactic acid (0.1-10 mM, 1 h) significantly inhibits LPS-induced inflammation in RAW blue macrophages and Caco-2 cells.
Indolelactic acid (0.1-10 mM, 1 h) inhibits TNF-α induced inflammation in HT-29 cells.
Indolelactic acid (10 mM, 1 h) activates the AhR and downstream Nrf2 pathway in Caco-2 cells.
Indolelactic acid (5 μM, 24 h) enhances the IFIT2 and RSAD2 mRNA expression in H4 cells stimulated by IL-1β.
In Vivo: Indolelactic acid (gavage feeding, 10 μM, 5 μL, 5 days, C57BL/6 mice) benefits the immature intestine preferentially.
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