YM-254890 产品活性：YM-254890 是一种从 Chromobacterium sp 中分离的选择性 Gαq/11 蛋白抑制剂。YM-254890 对其他 G 蛋白亚型无抑制作用。YM-254890 通过阻断 P2Y1 信号转导途径来抑制 ADP 诱导的血小板凝集，其 IC50 值低于 0.6 μM。 产品来源： https://www.medchemexpress.cn/ym-254890.html 研究领域：GPCR/G Protein 作用靶点：P2Y Receptor 结构分类：其他类 | 结构分类 In Vitro: YM-254890 inhibits platelet aggregation induced by ADP (2, 5 and 20 μM) in human platelet-rich plasma with IC50 values of 0.37, 0.39 and 0.51 μM. ADP mediates platelet aggregation via two G protein-coupled receptors, P2Y1 and P2Y12. The effect of YM-254890 on the P2Y1 and P2Y12 signal transduction pathways using C6-15 cells stably expressing the human P2Y1 or P2Y12 receptors is examined. Stimulation of P2Y1-C6-15 cells by 2MeSADP leads to increases in intracellular calcium mobilization. In this assay, YM-254890 inhibits the increase in [Ca2+]i with an IC50 value of 0.031 μM. In contrast, 2MeSADP-induced inhibition of forskolin-stimulated adenylyl cyclase activity in P2Y12-C6-15 cells is unaffected by YM-254890 at 40 μM. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Macrocyclic Compound Library | Ticagrelor | Clopidogrel | Sodium metatungstate | Uridine 5′-diphosphoglucose disodium salt | MRS 2578 | Uridine-5'-diphosphate disodium salt | Cangrelor tetrasodium | PPTN hydrochloride | Uridine triphosphate trisodium salt | UDP-Galactose disodium | Diquafosol tetrasodium | PSB-0739 | AR-C118925XX | BPTU | Prasugrel | 2-Methylthio-AMP | NF157 | P2Y2R/GPR17 antagonist 1 | N6-(4-Hydroxybenzyl)adenosine | MRS2500 tetraammonium | PIT | Vicagrel | AZD1283 | Elinogrel | MRS2179 tetrasodium hydrate | NF546 hydrate 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。