Diprotin A TFA 产品活性：Diprotin A TFA (Ile-Pro-Ile TFA) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。 产品来源： https://www.medchemexpress.cn/Diprotin_A_TFA.html 研究领域：Metabolic Enzyme/Protease 作用靶点：Dipeptidyl Peptidase In Vitro: Diprotin A increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor. In Vivo: In the model of retinopathy of prematurity, Diprotin A increases not only retinal vascularity but also leakage. Additionally, in the murine diabetic retinopathy model, Diprotin A increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway. 相关产品：Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Peptidomimetic Library | Anti-diabetic Compound Library | Peptide Library | Heterocyclic Compound Library | Metabolic Enzyme Compound Library | Protease Inhibitor Library | Bioactive Compound Library Max | Sitagliptin | Puromycin aminonucleoside | Talabostat mesylate | Linagliptin | Brensocatib | Saxagliptin | Vildagliptin | 1G244 | Omarigliptin | Diprotin A | Teneligliptin | Alogliptin Benzoate | Nateglinide | Anagliptin | Trelagliptin | Gemigliptin tartrate | K579 | γ-Glu-Tyr | DPP-IV-IN-2 | Retagliptin phosphate | UAMC00039 dihydrochloride | DPP-IV-IN-1 | Dutogliptin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。