Polygodial 产品活性：Polygodial (Poligodial) 是一种抗真菌 (antifungal) 增强剂。Polygodial 是一种倍半萜，具有抗痛觉过敏的作用。 产品来源： https://www.medchemexpress.cn/polygodial.html 研究领域：Anti-infection 作用靶点：Fungal 来源：植物 | 其他科 结构分类：萜类 | 倍半萜 | 结构分类 In Vitro: Polygodial exhibits fungicidal activity against Saccharomyces cerevisiae, Candida albicans, and other fungal pathogens in standardized susceptibility tests (NCCLS). Polygodial (12.5 μg/mL, 3 hours) induces significant shrinkage compared to controls in Saccharomyces cerevisiae cells with the minimum fungicidal concentration (MFC) for 106 CFU/mL in RPMI 1640 medium. In Vivo: Polygodial is a sesquiterpene isolated from the barks of Drymis winteri (Winteraceae). Polygodial (0.5 to 10 mg/kg; 0.5 h; given by i.p. route to mice) induces significant, dose-related and almost complete inhibition of Acetic acid, Kaolin and Zymosan-induced abdominal constrictions. The calculated mean ID50 values are 0.8, 2.1 and 2.6 mg/kg and maximal inhibitions of 90.0±3.0, 98.0±1.0 and 97.0±2.0 %, against Acetic acid, Kaolin and Zymosan, respectively. Polygodial is about 14- to 27-fold more potent than the hydroalcoholic extract (HE) at the ID50 level. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Immunology/Inflammation Compound Library | Natural Product Library | Antifungal Compound Library | Terpenoids Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Marine-Sourced Natural Product Library | Cysteine Targeted Covalent Library | Bioactive Compound Library Max | Rapamycin | Ferrostatin-1 | Cycloheximide | Staurosporine | Hygromycin B | Resveratrol | Tunicamycin | Oligomycin | Camptothecin | Filipin complex | Amphotericin B | Calcimycin | Monensin sodium | Nystatin | Ketoconazole | Itraconazole | Fluconazole | Valinomycin | Tofacitinib citrate | Caspofungin diacetate | Mycophenolic acid | Leptomycin B | Idarubicin hydrochloride | Toyocamycin | Terbinafine | Hyperoside | Saponins | Sinefungin | Carvacrol 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。