Aspidin BB 产品活性：Aspidin BB 是一种间苯三酚衍生物，可从 Dryopteris championii 地上部分中分离得到。Aspidin BB 具有抗癌活性。Aspidin BB 在人卵巢 HO-8910 细胞中诱导细胞周期停滞和细胞凋亡 (apoptosis)。 产品来源： https://www.medchemexpress.cn/aspidin-bb.html 研究领域：Apoptosis 作用靶点：Apoptosis | Bcl-2 Family | Caspase 来源：植物 | 鳞毛蕨科 | 阔鳞鳞毛蕨 In Vitro: Aspidin BB (0-100 μM, 24-72 h) significantly inhibits HO-8910 cell proliferation in a dose- and time-dependent manner. The IC50 values are 15.02, 25.79 and 68.81 μM after 72, 48 and 24 h treatment, respectively. Aspidin BB suppresses Bcl-2 expression and enhances Bax expression to desintegrate the outer mitochondrial membrane, then causes cytochrome c release which leads to the activation of effector caspase-3, and further cleaves the poly ADP-ribose polymerase (PARP) in the nucleus, finally induces cell apoptosis. Aspidin BB provokes S phase arrest in HO-8910 cells with up-regulation of pRb, E2F1, CDK2, cyclin E and cyclin A proteins. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Natural Product Library | Anti-Cancer Compound Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | Mitochondria-Targeted Compound Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Anti-Prostate Cancer Compound Library | Membrane Protein-targeted Compound Library | Cysteine Targeted Covalent Library | Cell Death Library | Multi-Target Compound Library | Mitophagy Compound Library | Bioactive Compound Library Max | MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | Venetoclax | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | Ruxolitinib | Monomethyl auristatin E 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。