3'-Sialyllactose 产品活性：3'-Sialyllactose (3'-SL) 是一种益生元，具有维持免疫稳态，发挥抗炎和抗关节炎的作用。3'-Sialyllactose 是毒性等级最低的普通碳水化合物，可用于炎症的研究。 产品来源： https://www.medchemexpress.cn/3-sialyllactose.html 研究领域：NF-κB 作用靶点：NF-κB 结构分类：其他类 | 结构分类 In Vitro: 3'-Sialyllactose (0-250 μM; 24-36 h) promotes and restores Col2a1 synthesis and accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines. 3'-Sialyllactose (0-250 μM; 24 h) activates the expression of Sox9 and inhibits NF-κB activation in chondrocytes. 3'-Sialyllactose (0-5000 μg/plate) shows no mutagenic effect with no evident growth inhibition and deposition in all strains in the presence or absence of metabolic activation. 3'-Sialyllactose (1250 μg/mL) induces no chromosomal aberrations and shows non-clastogenic effect in either the presence or absence of metabolic activation. In Vivo: 3'-Sialyllactose (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis. 3'-Sialyllactose (500, 1000 and 2000 mg/kg; orally administration; once) induces no micronuclei in the bone marrow cells of mice. 3'-Sialyllactose (oral administration; (500 to 1000 to 2000 mg/kg) every dose at 4-day intervals) shows the maximum tolerance dose (MTD) is greater than 2000 mg/kg in male and female beagle dogs. 3'-Sialyllactose shows a lethal dose (LD50) above 20 g/kg bw, the highest dose tested. 相关产品：Phorbol 12-myristate 13-acetate | Bortezomib | BAY 11-7082 | TAK-243 | JSH-23 | Shikonin | Sulfasalazine | Triptolide | Aspirin | Pyrrolidinedithiocarbamate ammonium | Baicalin | Dihydroartemisinin | 5-Aminosalicylic Acid | Parthenolide | CBL0137 hydrochloride | Isoginkgetin | BAY 11-7085 | Rocaglamide | Betulinic acid | SC75741 | Astaxanthin | Ergothioneine | QNZ | Andrographolide | SN50 | Nafamostat mesylate | 20(S)-Ginsenoside Rg3 | Hyperoside | Ginsenoside Rg1 | Lidocaine 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。