Kynurenic acid sodium 产品活性：Kynurenic acid sodium 是一种内源性色氨酸代谢物，是针对靶点 NMDA, glutamate, α7 nicotinic acetylcholine receptor 的光谱性拮抗剂。Kynurenic acid sodium 也是 GPR35/CXCR8 的激动剂。 产品来源： https://www.medchemexpress.cn/Kynurenic_acid_sodium.html 研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling | Apoptosis | Metabolic Enzyme/Protease | Immunology/Inflammation | GPCR/G Protein 作用靶点：iGluR | Apoptosis | Endogenous Metabolite | CXCR | GPR35 结构分类：生物碱 | 喹啉类生物碱 | 结构分类 In Vitro: GPR35 functions as a receptor for the kynurenine pathway intermediate kynurenic acid. Kynurenic acid elicits calcium mobilization and inositol phosphate production in a GPR35-dependent manner in the presence of G qi/o chimeric G proteins. Kynurenic acid stimulates [35S]guanosine 5′-O-(3-thiotriphosphate) binding in GPR35-expressing cells, an effect abolished by pertussis toxin treatment. Kynurenic acid also induces the internalization of GPR35. KYNA’s neuroinhibitory qualities and its neuroprotective and anticonvulsant effects are discovered using concentrations of the compound in the millimolar range. This, as well as the low affinity of KYNA at each of the three ionotropic glutamate receptors responsible for these effects [NMDA, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate], together with the realization that KYNA concentrations in the mammalian brain are in the sub-micromolar range, suggested that other receptors might serve as targets of endogenous Kynurenic acid. Kynurenic acid, with a shallower inhibition curve and non-competitively, antagonizes α7nAChRs on cultured hippocampal neurons with an IC50 in the low micromolar range. In Vivo: Kynurenic acid affects the activity of leukocytes in the peripheral blood of mice, although the lowest one (2.5 mg/L) has the most profound influence in contrast to the highest one (250 mg/L), which produces the weakest effect. The lowest Kynurenic acid dose stimulates the proliferative response of T lymphocytes (p<0.05), after 7 and 28 days of administering the acid to the animals. 相关产品：Natural Product Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Membrane Transporter/Ion Channel Compound Library | Metabolism/Protease Compound Library | Neuronal Signaling Compound Library | Natural Product Library | Clinical Compound Library | Human Endogenous Metabolite Compound Library | Small Molecule Immuno-Oncology Compound Library | Endocrinology Compound Library | Neurotransmitter Receptor Compound Library | Anti-Alzheimer's Disease Compound Library | Neuroprotective Compound Library | Alkaloids Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Food-Sourced Compound Library | Antidepressant Compound Library | Human Metabolite Library | Chemokine Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Animal-Sourced Natural Product Library | Cell Death Library | Ion Channel Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | MG-132 | Rapamycin | 3-Methyladenine | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | ATP | Retinoic acid | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。