Prostratin 产品活性：Prostratin 是一种天然的二萜类物质，为 PKC 的激活剂，Ki 值为 12.5 nM，同时可抑制 HIV-1 的活性。 产品来源： https://www.medchemexpress.cn/prostratin.html 研究领域：Epigenetics | TGF-beta/Smad | Anti-infection 作用靶点：PKC | HIV 来源：植物 | 瑞香科 | 河朔荛花 结构分类：萜类 | 二萜 | 结构分类 In Vitro: Prostratin inhibits [3H]PDBu binding to the CEM cells with a Ki of 210 nM. Prostratin (125-1000 nM) dose-dependently inhibits the growth of acute myeloid leukemia (AML) cell lines (HL-60, NB4, and U937 cells). Prostratin (125-100 nM) induces G1 arrest of AML cells and affects the cell-cycle-related molecules (pRb phosphorylation, CDKs, and p21) in HL-60 cells. Prostratin also causes differentiation in AML cell lines via activation of PKC. Furthermore, PKC-dependent activation of the MEK/ERK/MAP signaling pathway requires differentiation induced by Prostratin. Prostratin induces HIV-1 transcription activation requiring active form of PKD3. Prostratin also activates PKD3 via PKCε of novel PKC subfamily. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Phorbol 12-myristate 13-acetate | Chloroquine | Doxorubicin hydrochloride | Forskolin | Staurosporine | 5-Fluorouracil | Ionomycin | Q-VD-OPh | Valproic acid | Panobinostat | Go 6983 | Shikonin | Probenecid | Kaempferol | Dimethyl fumarate | Hydroxyurea | Plerixafor | Maraviroc | Birinapant | Baicalin | Mitoxantrone | Midostaurin | Flavopiridol | Ritonavir | Ivermectin | Fasudil Hydrochloride | Ebselen 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。