Teverelix 产品活性：Teverelix (EP 24332) 是一种 GnRH 拮抗剂。Teverelix 可竞争性和可逆性地与 GnRH 受体 (GnRH receptors) 结合，从而抑制 LH 和 FSH 的释放。Teverelix 可用于前列腺增生、子宫内膜异位症和前列腺癌的研究。 产品来源： https://www.medchemexpress.cn/teverelix.html 研究领域：GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation 作用靶点：GnRH Receptor | Histamine Receptor In Vitro: Teverelix (10 nM, 45 mins) inhibits GnRH-induced intracellular Ca2+ increase in HEK293/GnRHR cells. Teverelix (0.1 nM-1 μM, 45 mins) inhibits GnRH-induced cAMP accumulation in HEK293/GnRHR cells. Teverelix (10 nM-1 μM, 15 mins) inhibits GnRH-induced pERK1/2 and pCREB activation in HEK293/GnRHR cells. Teverelix inhibits histamine release in a peritoneal rat mast cell, with an EC50value of 81 μg/mL. In Vivo: Teverelix (3-300 μg/kg, intramuscular injection) inhibits testosterone in rats. Teverelix (1 mg/kg, s.c, daily for 3 days) abolishes luteal function in stumptailed macaques. 相关产品：Histamine | Clemastine fumarate | Degarelix | Astemizole | Cimetidine | Terfenadine | Amitriptyline hydrochloride | Loratadine | Mecamylamine hydrochloride | Desloratadine | Goserelin acetate | Cetrorelix Acetate | Diphenhydramine hydrochloride | Doxepin Hydrochloride | Osthole | Famotidine | Fexofenadine hydrochloride | Perphenazine | (S)-(+)-Dimethindene maleate | Promethazine hydrochloride | Ketotifen fumarate | Benztropine mesylate | Ritanserin | Lodoxamide | Mepyramine maleate | Mianserin hydrochloride | Cetirizine dihydrochloride | Chlorpheniramine maleate | Mirtazapine | Ebastine 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。