耗材描述
Pexiganan
产品活性:Pexiganan (MSI 78 free base) 是 magainin 2 的合成形式类似物。Pexiganan 是一种强效且具有口服活性的广谱抗菌肽。Pexiganan 可用于感染相关的研究,如糖尿病足溃疡感染。
产品来源: https://www.medchemexpress.cn/pexiganan.html
研究领域:Anti-infection
作用靶点:Bacterial
结构分类:其他类 | 结构分类
In Vitro: Pexiganan (MIC: 0-128 μg/mL approximately) shows broad-spectrum antibacterial activity against 3,109 clinical isolates of gram-positive and gram-negative, anaerobic and aerobic bacteria.
Pexiganan (4 μg/mL) inhibits gastric ulcer strain and gastric cancer strain.
In Vivo: Pexiganan (1, 3, 10 or 30 mg/kg, p.o., daily for three consecutive days) shows H. pylori clearance efficiency in H. pylori-infected mouse.
Pexiganan (1 mg/kg, i.p.) shows antimicrobial activity in rat models of Gram-negative septic shock.
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