NucPE1 产品活性：NucPE1 (Nuclear Peroxy Emerald 1) 是核定位荧光过氧化氢探针, 其特异性定位于细胞核，没有附加的靶向部分。 产品来源： https://www.medchemexpress.cn/NucPE1.html 研究领域：Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease 作用靶点：Reactive Oxygen Species In Vitro: NucPE1 features two major visible region absorptions (λabs=468 nm, ε=27,300 M-1cm-1; λabs=490 nm, ε=26,000 M-1cm-1) and a weak emission (λem=530 nm, Φ=0.117). Reaction of NucPE1 with H2O2 triggers a fluorescence increase upon its conversion to fluorophore NucPE1, which possesses one major absorption band at 505 nm (ε=19,100 M-1cm-1) with enhanced emission (λem=530 nm, Φ=0.626). NucPE1 selectively accumulates in the nuclei of a variety of mammalian cell lines as well as in whole model organisms like C. clegans, where it can respond to subcellular changes in H2O2 fluxes. In Vivo: NucPE1 maintains the ability to selectively target nuclei in vivo. NucPE1 imaging reveals a reduction in nuclear H2O2 levels in worms overexpressing sir-2.1 compared to wildtype congeners, supporting a link between this longevity-promoting sirtuin protein and enhanced regulation of nuclear ROS pools. 相关产品：Acetylcysteine | H2DCFDA | Deferoxamine mesylate | MitoSOX Red | Elesclomol | Quercetin | L-Ascorbic acid | Mito-TEMPO | Mitoquinone mesylate | Sulforaphane | L-Glutathione reduced | Trolox | Dimethyl fumarate | Zinc Protoporphyrin | FX-11 | Diphenyleneiodonium chloride | Urolithin A | Sodium dichloroacetate | Berberine chloride | TPEN | α-Vitamin E | Ciprofloxacin | 2-Methoxyestradiol | Coenzyme Q10 | Tempol | GSK2795039 | Trabectedin | Chlorogenic acid | Uric acid | Gallic acid 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。