Methyl-β-cyclodextrin 产品活性：Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) 是一种环庚糖，对非极性物质有增溶作用，广泛应用于疏水性活性分子的释放。Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) 也广泛用作降胆固醇剂。Methyl-β-cyclodextrin 可显著降低网格蛋白依赖性内吞作用。Methyl-β-cyclodextrin 可阻断细胞迁移体的形成。 产品来源： https://www.medchemexpress.cn/Methyl-_beta_-cyclodextrin.html 研究领域：Others 作用靶点：Biochemical Assay Reagents In Vitro: Methyl-β-cyclodextrin is extensively used to increase the permeability of cells, and thereby increase the uptake of small molecules such as glucose and nano-particles. Cyclodextrins are a family of cyclic oligosaccharides with a hydrophilic outer surface and a lipophilic central cavity. Cyclodextrins molecules are relatively large with a number of hydrogen donors and acceptors and, thus in general, they do not permeate lipophilic membranes. In the pharmaceutical industry, cyclodextrins have mainly been used as complexing agents to increase aqueous solubility of poorly soluble drugs and to increase their bioavailability and stability. Cyclodextrins are used in pharmaceutical applications for numerous purposes, including improving the bioavailability of drugs. Methyl-β-cyclodextrin quickly induces caspase-dependent apoptosis in PEL cells via cholesterol depletion from the plasma membrane. Methyl-β-cyclodextrin inhibits the growth of all PEL cell lines in a dose-dependent manner. The IC50 is 3.33-4.23 mM in each cell line. Methyl-β-cyclodextrin is a highly water soluble cyclic heptasaccharide consisting of a β-glucopyranose unit, has been reported as the most effective agent for the depletion of cholesterol from cells among the various cholesterol-depleting agents. In Vivo: In a PEL xenograft mouse model, Methyl-β-cyclodextrin significantly inhibits the growth and invasion of PEL cells without apparent adverse effects. Methyl-β-cyclodextrin-treated mice appears to be healthy, whereas non-treated mice has a distended abdominal region. The body weights of control are significantly higher than those of Methyl-β-cyclodextrin treated mice. Methyl-β-cyclodextrin-treated mice has a significantly lower volume of ascites than that of non-treated mice. Studies in both humans and animals have shown that cyclodextrins can be used to improve drug delivery from almost any type of drug formulation. Currently, there are approximately 30 different pharmaceutical products worldwide containing drug/cyclodextrins complexes in the market. 相关产品：PEG300 | Tween 80 | Corn oil | SBE-β-CD | Hexadimethrine bromide | Solutol HS-15 | HP-β-CD | Cremophor EL | Sodium carboxymethyl cellulose (Viscosity:800-1200 mPa.s) | DL-dithiothreitol | IPTG | Phosal 50 PG | PLGA (50:50) | EGTA | Ac4ManNAz (80% α isomer) | Methyl cellulose | Bovine Serum Albumin | DTNB | FITC-Dextran (MW 70000) | LysoTracker Red | Biotin-azide | 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride | Trifluoromethanesulfonic acid silver | Ethylenediaminetetraacetic acid | NAI-N3 | Gelucire 44/14 | HEPES | Formamide | Glyco-diosgenin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。