Spiramide 产品活性：Spiramide (AMI-193) 是一种有效和选择性的 5-HT2 和 dopamine D2 受体拮抗剂，Ki 值分别为 2 nM 和 3 nM。Spiramide 对 5-HT2 受体的选择性与 5-HT1C 受体 (Ki=4300 nM) 相比大于 2000 倍。Spiramide 具有抗精神病活性。 产品来源： https://www.medchemexpress.cn/spiramide.html 研究领域：GPCR/G Protein | Neuronal Signaling 作用靶点：5-HT Receptor | Dopamine Receptor 来源：植物 | 蔷薇科 | 粉花绣线菊 结构分类：生物碱 | 哌啶类生物碱 In Vitro: Spiramide retains affinity for 5-HT1A sites (Ki=50 nM) and also binds at dopamine D2 sites (Ki=3 nM), but possesses low affinity for dopamine D1 sites (Ki=2530 nM). In Vivo: AMI-193 (0.003-0.01 mg/kg; i.m.) dose-dependently decreases response rate in monkeys under a fixed-interval (FI) schedule of stimulus termination. AMI-193 (0.003-0.01 mg/kg; i.m.) attenuates the discriminative-stimulus effects of cocaine in drug-discrimination experiments. AMI-193 (0.003-0.01 mg/kg; i.m.) reduces response rate under a second-order schedule of i.v. self-administration of cocaine (0.1 mg/infusion). 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | Natural Product Library | Neurotransmitter Receptor Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Alzheimer's Disease Compound Library | Alkaloids Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Targeted Diversity Library | Plant-Sourced Natural Product Library | 5-HT Receptor Compound Library | Coagulation and Anti-coagulation Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Mitochondrial Toxicity Compound Library | Highly Selective Inhibitors Library | Dopamine Receptor Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Clozapine N-oxide | MPTP hydrochloride | Oxidopamine hydrobromide | Chlorpromazine hydrochloride | L-DOPA | Serotonin hydrochloride | Dopamine hydrochloride | SCH-23390 hydrochloride | Harmine | Puerarin | Haloperidol | Pimozide | PNU-282987 | SKF 38393 hydrochloride | Scopolamine hydrobromide | Risperidone | Cabergoline | Vortioxetine | Olanzapine | Dihydroergotamine mesylate | Aripiprazole | Bromocriptine mesylate | GTS-21 dihydrochloride | Fluphenazine dihydrochloride 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。