耗材描述
Tubercidin
产品活性:Tubercidin (7-Deazaadenosine) 是一种从 Streptomyces tubercidicus 获得的抗生素,抑制粪链球菌 (8043) 生长的 IC50 值为 0.02 μM。Tubercidin 通过结合 DNA 或 RNA 抑制聚合酶,从而抑制 DNA 复制,RNA 和蛋白质合成。Tubercidin 是腺苷磷酸化酶的弱抑制剂,并干扰腺苷和 AMP 的磷酸化。Tubercidin 具有抗病毒活性。
产品来源: https://www.medchemexpress.cn/Tubercidin.html
研究领域:Anti-infection | Cell Cycle/DNA Damage
作用靶点:Bacterial | DNA/RNA Synthesis | Influenza Virus | Antibiotic
结构分类:抗生素 | 疾病研究 | 抗菌 | 抗生素 | 疾病研究 | 抗病毒 | 抗生素 | 其他类 | 结构分类
In Vitro: Tubercidin (7-Deazaadenosine) (0-10 nM; 14 days) has a dose-dependent inhibitory effect on myeloid and erythroid human bone marrow progenitor cells, and the IC50s of tubercidin are 3.4 nM and 3.7 nM for CFU-GM and BFU-E, respectively[3].
In Vivo: Tubercidin (7-Deazaadenosine) (intraperitoneal injection; 5 mg/kg; 10 days) in cooperation with NBMPR-P protects the mice from the lethality of tubercidin and allowed the repetition of the regimen for a second time with 100% survival.
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