DZ2002 产品活性：DZ2002 是一种口服有效的、可逆的、低细胞毒性的 III 型 SAHH 抑制剂 (Ki=17.9 nM)，具有较好的免疫抑制活性。DZ2002 能通过逆转各种细胞类型的促纤维化表型来防止实验性皮肤纤维化的发展。DZ2002 可用于自身免疫性疾病，如狼疮综合征和系统性硬化症的研究。 产品来源： https://www.medchemexpress.cn/DZ2002.html 研究领域：Others 作用靶点：Others In Vitro: DZ2002 (0.1, 1, 10 µM; 96 h) inhibits the mixed lymphocyte reaction (MLR) response. DZ2002 (0.1, 1, 10 µM; 24 h) inhibits IL-12 and TNF-α production from both mouse peritoneal exudate cells and humanTHP-1 Cells. DZ2002 (0.1, 1, 10 µM; 64 h) inhibits expression of B7 (CD80/CD86) on differentiated THP-1 cells. In Vivo: DZ2002 (2, 10, 50 mg/kg; i.p.; twice) blocks the DNFB-induced DTH response. (DNFB-induced DTH is a Th1 cell-mediated immune response, in which IL-12 is highly expressed and macrophages have been shown to play an important role). DZ2002 (0.08, 2 mg/kg; i.p.; single daily for 7 days) significantly suppresses a delayed-type hypersensitivity reaction as well as antibody secretion. DZ2002 (50, 100 mg/kg; p.o.; single daily for 4 weeks) exerts a potent anti-fibrotic effect on dermal fibrosis by reducing the production of collagen, facilitating its degradation and regulating expression of various soluble factors in SSc mice model. 相关产品：Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Orally Active Compound Library | Human Metabolite Library | Heterocyclic Compound Library | Bioactive Compound Library Max | Digitonin | 5-Ph-IAA | FLAG peptide | 3X FLAG peptide | TCEP hydrochloride | Monocrotaline | Tocofersolan | Pronase E (Activity ≥ 7000 U/g) | DPPH | DNase I, Bovine pancreas | NMDI14 | O-Propargyl-Puromycin | Human IgG1 kappa, Isotype Control | Phytohemagglutinin | Hyaluronidase | Biotinyl tyramide | MYLS22 | Pertussis Toxin | N,N-Dimethylformamide | Kifunensine | OVA Peptide (323-339) | L-Tryptophan | 6-Aminonicotinamide | Lauryl maltose neopentyl glycol | Alkyne-phenol | Potassium oxonate | OVA Peptide(257-264) TFA | CHAPS | Teriparatide 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。