Vipadenant 产品活性：Vipadenant (BIIB-014; CEB-4520) 是腺苷受体拮抗剂，抑制 A2A 和 A1 活性的 Ki 值分别为 1.3 nM 和 68 nM。 产品来源： https://www.medchemexpress.cn/Vipadenant.html 研究领域：GPCR/G Protein 作用靶点：Adenosine Receptor In Vivo: Vipadenant (0.3-30 mg/kg) produces a dose-dependent reduction in catalepsy. Vipadenant (10 mg/kg) does not produce any statistically significant dyskinetic episodes in 6-OHDA-lesioned rats during a 19-day dosing regimen. In the mouse and rat haloperidol-induced hypolocomotion models, vipadenant has a minimum effective dose of 0.1 and 1 mg/kg, respectively. Vipadenant (3 and 10 mg/kg, p.o.) is able to increase contralateral rotations in 6-OHDA lesioned rats. 相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Clinical Compound Library | Small Molecule Immuno-Oncology Compound Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | Neurotransmitter Receptor Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Human Metabolite Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Bioactive Compound Library Max | 5'-N-Ethylcarboxamidoadenosine | Inosine | Theophylline | CGS 21680 Hydrochloride | ZM241385 | SCH 58261 | Istradefylline | Etrumadenant | BAY 60-6583 | DPCPX | Ciforadenant | Imaradenant | Namodenoson | Regadenoson | Piclidenoson | MRS 1754 | PSB-603 | Adenosine 5'-monophosphate monohydrate | SCH442416 | Nitrobenzylthioinosine | Preladenant | N6-Cyclopentyladenosine | Theobromine | Aminophylline | Derenofylline | MRS 1523 | Ticlopidine hydrochloride | Inupadenant | MRS-1706 | MRS-1191 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。