SC79 产品活性：SC79，一个特异的、能透过血脑屏障的 Akt 激动剂，可激活胞质中 Akt，并抑制 Akt 膜转位。SC79 特异性结合Akt 的PH 结构域。 产品来源： https://www.medchemexpress.cn/SC79.html 研究领域：PI3K/Akt/mTOR 作用靶点：Akt In Vitro: SC79 augmentes Akt phosphorylation at both the Thr308 and S473 sites.? SC79 (10.96 μM) induces cytosolic phosphorylation of Akt. SC79 enhances IGF1-induced Akt phosphorylation in both serum-starved cells and cells grown in serum-rich medium.? SC79 reduces neuronal excitotoxicity and prevents stroke-induced neuronal death. SC79 suppresses PHAKTM-GFP plasma membrane translocation. ? SC79 restores proliferation of BRAT1 knockdown cells, and reduces the production of superoxide in mitochondria of MitoSox positive cells.? SC79 upregulates FLIPL/S expression and consequently suppresses caspase-8 activation. In Vivo: SC79 treatment, even at much high dose (0.4 mg/g of body weight), does not induce any detectable changes in body weight, survival rate, appearance, and behavior in mice.? SC79 (10 mg/kg, i.p.) protects C57BL/6 mice from fas-induced fulminant hepatic failure.? SC79 protects hepatocytes from TNFα-mediated apoptosis and mice from Gal/LPS-induced liver injury and damage. 相关产品：Bioactive Compound Library Plus | Deferoxamine mesylate | MK-2206 dihydrochloride | Yoda 1 | Capivasertib | Afatinib | Ipatasertib | Chloramphenicol | Honokiol | Oridonin | Isoginkgetin | AKT inhibitor VIII | α-Linolenic acid | Artemisinin | GSK-690693 | Scutellarin | Ergothioneine | Recilisib | Guggulsterone | Miransertib | Afuresertib | Uprosertib | Patritumab | ZINC00640089 | Heclin | (Z)-Guggulsterone | PRE-084 hydrochloride | Perifosine | A-443654 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。