VU0361737 产品活性：VU0361737 (ML-128) 是一种高效、选择性的，中枢神经系统 (CNS) 渗透性的代谢型谷氨酸受体 4 正变构调节剂 (mGluR4 PAM)，对人类和大鼠 mGluR4 作用的 EC50 值分别为 240 nM 和 110 nM。VU0361737 具有神经保护作用，有潜力用于帕金森氏病的研究。 产品来源： https://www.medchemexpress.cn/VU0361737.html 研究领域：GPCR/G Protein | Neuronal Signaling 作用靶点：mGluR In Vitro: VU0361737 displays weak activity at mGlu5 and mGlu8 receptors and inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors. VU0361737 (1-10 μM) partially attenuates the Staurosporine (HY-15141)- and Doxorubicin (HY-15142)-evoked cell death on human neuroblastoma SH-SY5Y cells. In Vivo: VU0361737 exhibits terminal elimination half-lives (rat 1.9 h) due to high plasma clearance (894 mL/min/kg) following Intraperitoneal injection ( rat 10 mg/kg). 相关产品：Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | CNS-Penetrant Compound Library | Neurotransmitter Receptor Compound Library | Neuroprotective Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Targeted Diversity Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Activators Library | Allosteric Modulators (AMs) Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | L-Glutamine | Xanthurenic acid | LY341495 | Ro 67-7476 | DHPG | MPEP Hydrochloride | Eglumegad | MTEP hydrochloride | CHPG sodium salt | CTEP | (RS)-MCPG | JNJ16259685 | LY367385 hydrochloride | LY404039 | LY379268 | O-Phospho-L-serine | NPS 2390 | Dipraglurant | LY2794193 | MMPIP hydrochloride | Foliglurax monohydrochloride | Basimglurant | CDPPB | Mavoglurant 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。