Pirmenol hydrochloride 产品活性：Pirmenol ((±)-Pirmenol) hydrochloride 是一种具有口服活性的抗心律失常剂。Pirmenol hydrochloride 通过阻断毒蕈碱性受体 (mAchR) 来抑制 IK.ACh (IC50: 0.1 μM)。Pirmenol hydrochloride 可用于心血管疾病的研究，如心房颤动。 产品来源： https://www.medchemexpress.cn/Pirmenol-hydrochloride.html 研究领域：GPCR/G Protein | Neuronal Signaling | Membrane Transporter/Ion Channel 作用靶点：mAChR | Potassium Channel In Vitro: Pirmenol (1 μM) hydrochloride inhibits the IK.ACh induced by carbachol or intracellular loading of GTPg S in in atrial cells. Pirmenol (5 μM) hydrochloride depresses the early part of the plateau and lengthened the final repolarization of the action potentials in ventricular myocytes. Pirmenol (1 μM) hydrochloride prolongs the action potential duration at 90% repolarization in atrial muscles and Purkinje fibers. In Vivo: Pirmenol (2.5 and 5 mg/kg, p.o.) hydrochloride is effective against the arrhythmias in conscious, coronary artery ligated dogs. Pirmenol (rats) hydrochloride shows LD50s of 359.9 mg/kg (p.o), 23.6 mg/kg (i.v.). Pirmenol (mice) hydrochloride shows LD50s of 215.5 mg/kg (p.o), 20.8 mg/kg (i.v.). 相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | Anti-Cardiovascular Disease Compound Library | Orally Active Compound Library | Neurotransmitter Receptor Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Alzheimer's Disease Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Potassium Channel Compound Library | Heterocyclic Compound Library | Off-patent Drug Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Ion Channel Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Nigericin sodium salt | Clozapine N-oxide | Yoda 1 | BAPTA-AM | Deschloroclozapine | Minocycline hydrochloride | Pilocarpine Hydrochloride | Branaplam | Rosuvastatin Calcium | SCH-23390 hydrochloride | Atropine | Glibenclamide | Quinidine (15% dihydroquinidine) | Carbamazepine | Tetrandrine | E-4031 | DCPIB | Minoxidil | Amiodarone hydrochloride | 20(S)-Ginsenoside Rg3 | Scopolamine hydrobromide | Guanosine 5'-diphosphate disodium salt | Tannic acid | Carbamoylcholine chloride | Quinine | TRAM-34 | Olanzapine 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。