Ac-Gly-BoroPro 产品活性：Ac-Gly-BoroPro是选择性的 FAP 抑制剂，Ki 值为23 nM。 产品来源： https://www.medchemexpress.cn/Ac-Gly-BoroPro.html 研究领域：Immunology/Inflammation 作用靶点：FAP In Vitro: FAP has been implicated in cancer; however, its specific role remains elusive because inhibitors that distinguish FAP from other prolyl peptidases like dipeptidyl peptidase-4 (DPP-4) have not been developed. Ac-Gly-BoroPro selectively inhibits FAP relative to other prolyl peptidases. FAP reacts readily with submicromolar concentrations of Ac-Gly-BoroPro, reaching steady state inhibition levels rapidly (Ki=23±3 nM). In contrast, DPP-4 requires higher Ac-Gly-BoroPro concentrations for inhibition and a longer time to reach steady state inhibition levels (Ki=377±18 nM). Ac-Gly-BoroPro inhibits other prolyl peptidases (DPP-7, DPP-8, DPP-9, prolyl oligopeptidase, and acylpeptide hydrolase) with Ki values ranging from 9- to 5400-fold higher than that for FAP inhibition. The N-acyl-linkage in Ac-Gly-BoroPro blocks the N terminus of the inhibitor, making it less nucleophilic and therefore unlikely to cyclize. 相关产品：Bioactive Compound Library Plus | FAPI-46 | FAPI-4 | FAP-2286 | Sibrotuzumab | Suc-Gly-Pro-AMC | NH2-UAMC1110 TFA | OncoFAP | FAP-IN-2 TFA | NOTA-FAPI | FAPI-34 | 3BP-3940 | FAPI-2 | AlF-PD-FAPI | ARI-3099 | FAP-IN-1 | FAPI-2 TFA | FAPI-74 | Fluorogen binding modulator-1 | FSDD0I | FSDD1I | FSDD3I | PNT6555 | SB03178 | Zilganersen | Zilganersen sodium | [99mTc]Tc-6–1 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。