BMS-813160 产品活性：BMS-813160 是有效的、选择性的 CCR2/5 的双拮抗剂。BMS-813160 与 CCR2 和 CCR5 结合，IC50 分别为 6.2 和 3.6 nM。BMS-813160 可用于炎症的研究。 产品来源： https://www.medchemexpress.cn/BMS-813160.html 研究领域：GPCR/G Protein | Immunology/Inflammation 作用靶点：CCR In Vitro: BMS-813160 binds with CCR2, CCR5, CCR1, CCR4 and CXCR2 with IC50s of 6.2 nM, 3.6 nM, ＞25 μM, ＞40 μM and ＞40 μM, respectively. BMS-813160 shows activities to CCR2 CTX, CCR2 CD11b, CCR5 CTX and CCR5 CD11b with IC50s of 0.8, 4.8, 1.1 and 5.7 nM, respectively. In Vivo: BMS-813160 (10-160 mg/kg; p.o. twice a day for two days) inhibits the migration of inflammatory monocytes and macrophages in mouse thioglycollate-induced peritonitis model, and shows excellent oral bioavailability. 相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Small Molecule Immuno-Oncology Compound Library | Drug Repurposing Compound Library | Anti-Cardiovascular Disease Compound Library | Endocrinology Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Chemokine Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Cytokine Inhibitors Library | Multi-Target Compound Library | Bioactive Compound Library Max | Pirfenidone | Maraviroc | RS 504393 | Bindarit | BX471 | INCB3344 | RS102895 hydrochloride | Cenicriviroc | PF-4136309 | TAK-779 | Zelnecirnon | CCR6 antagonist 1 | CCR6 inhibitor 1 | AZ084 | ZK756326 dihydrochloride | AZD2098 | C-021 | GW 766994 | R243 | Tivumecirnon | 7,4'-Dihydroxyflavone | CCR2 antagonist 4 hydrochloride | K777 | Vercirnon | CCR7 Ligand 1 | J-113863 | MK-0812 Succinate | BI-6901 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。