Purfalcamine 产品活性：Purfalcamine 是一种具有口服活性，选择性的恶性疟原虫钙依赖性蛋白激酶 1 (PfCDPK1) 抑制剂，IC50 为 17 nM，EC50 为 230 nM。Purfalcamine 具有抗疟疾活性，可以引起疟原虫在裂殖体阶段的发育停滞。 产品来源： https://www.medchemexpress.cn/purfalcamine.html 研究领域：Anti-infection 作用靶点：Parasite In Vitro: Purfalcamine has low activity against Toxoplasma gondii calcium-dependent protein kinase 3 (TgCDPK3). Purfalcamine (225, 450 nM) has no effect on the parasitemia in the first 32 hours. After about 40 hours, parasite level remains stable and then begins dropping. Purfalcamine inhibits proliferation with EC50s of 171-259 nM for P. falciparum strains (3D7, Dd2, FCB, HB3 and W2), which indicates effectiveness against drug-resistant parasites. Given that the EC50 value for P. falciparum (3D7) is 230 nM, Purfalcamine shows a therapeutic window ranging from 23-fold to 36-fold (EC50s for CHO=12.33 μM, HEp2=7.235 μM, HeLa=7.029 μM and Huh7=5.476 μM). In Vivo: Purfalcamine (10 mg/kg; oral gavage; BID; for 6 days) demonstrates a delay in the onset of parasitemia in treated mice. Purfalcamine (20 mg/kg; orally gavage) exhibits a Cmax of 2.6 μM with a half-life of 3.1 hours. 相关产品：Bioactive Compound Library Plus | Anti-Infection Compound Library | Orally Active Compound Library | Antiparasitic Compound library | Heterocyclic Compound Library | Highly Selective Inhibitors Library | Multi-Target Compound Library | Bioactive Compound Library Max | Chloroquine | Puromycin dihydrochloride | Hygromycin B | Doxycycline hyclate | Acetaminophen | Anisomycin | Metronidazole | Kaempferol | Amphotericin B | Hydroxychloroquine | Monensin sodium | Dihydroartemisinin | Niclosamide | Berberine chloride | Artesunate | Acridine Orange hydrochloride | Ivermectin | Eflornithine hydrochloride hydrate | Azithromycin | TPE-MI | Halofuginone | Ibuprofen | Artemisinin | 5'-Methylthioadenosine | RRx-001 | Cepharanthine | Betulinic acid 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。