TAK-071 产品活性：TAK-071是一种新型, 高效，选择性的毒蕈碱乙酰胆碱受体1 (M1R)正变构调节剂。 TAK-071激活M1R的EC50为520nM。 产品来源： https://www.medchemexpress.cn/TAK-071.html 研究领域：GPCR/G Protein | Neuronal Signaling 作用靶点：mAChR In Vivo: TAK-071 increase hippocampal inositol monophosphate production through M1R activation and improved DB00747 -induced cognitive deficits in rats at 0.3 mg/kg. TAK-071 also induce diarrhea at 10 mg/kg in rats. Combining sub-effective doses of TAK-071 (3 mg/kg) with an acetylcholinesterase inhibitor significantly ameliorates DB00747-induced cognitive deficits in rats. 相关产品：Covalent Screening Library Plus | Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | Clinical Compound Library | Drug Repurposing Compound Library | Covalent Screening Library | Neurotransmitter Receptor Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Allosteric Modulators (AMs) Compound Library | Bioactive Compound Library Max | Clozapine N-oxide | Deschloroclozapine | Pilocarpine Hydrochloride | Atropine | Scopolamine hydrobromide | Carbamoylcholine chloride | Olanzapine | Amitriptyline hydrochloride | Methacholine chloride | Xanomeline | Mepenzolate bromide | (S)-(+)-Dimethindene maleate | Promethazine hydrochloride | Propantheline bromide | Benztropine mesylate | Oxotremorine M iodide | Arecoline hydrobromide | Darifenacin hydrobromide | Tiotropium Bromide | DREADD agonist 21 | Pirenzepine dihydrochloride | Dronedarone 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。