Pifithrin-α, p-Nitro, Cyclic 产品活性：Pifithrin-α, p-Nitro, Cyclic (PFN-α)，是细胞通透性的 p53 抑制剂。Pifithrin-α, p-Nitro, Cyclic 对暴露于 Etoposide 的皮层神经元的保护作用比 Pifithrin-α 强一个数量级 (ED50=30 nM)。Pifithrin-α, p-Nitro, Cyclic 也作为 p53 转录后活性抑制剂。Pifithrin-α, p-Nitro, Cyclic 不阻止 p53 上的 S15 残基磷酸化。 产品来源： https://www.medchemexpress.cn/pifithrin-alpha-p-nitro-cyclic.html 研究领域：Apoptosis 作用靶点：MDM-2/p53 In Vitro: Pifithrin-α, p-Nitro, Cyclic (PFN-α) efficiently blocks p53-triggered cell death and p21/WAF1 expression in cortical neurons exposed to etoposide at concentrations one order magnitude lower than that in PFT-α. In Vivo: Intraocular injection of pifithrin-α slightly increases survival of retinal ganglion cell (RGC) at the concentration of 6 μM but not at 0.06 μM. Pifithrin-α, p-Nitro, Cyclic (PFN-α) is not effective in vivo, even at 6 μM. Pifithrin-α, p-Nitro, Cyclic shows the half-life (t1/2) of 6 hours (when incubated in biological conditions). 相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Ferroptosis Compound Library | Pyroptosis Compound Library | Glutamine Metabolism Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Transcription Factor-Targeted Library | Heterocyclic Compound Library | Anti-Hematopathy Compound Library | Bioactive Compound Library Max | Nutlin-3a | Minocycline hydrochloride | Pifithrin-α hydrobromide | Idasanutlin | GSK3326595 | Navtemadlin | Eprenetapopt | CBL0137 hydrochloride | UC2288 | Amifostine | MD-224 | Siremadlin | RG7112 | Milademetan | NSC319726 | Pifithrin-μ | Alrizomadlin | Pifithrin-β hydrobromide | Higenamine hydrochloride | Kevetrin hydrochloride | COTI-2 | C16-Ceramide | RITA | NVP-CGM097 | p53 Activator 7 | Flubendazole | SP-141 | CP-31398 dihydrochloride 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。