GSK-25 产品活性：GSK-25 是一种有效的、选择性的，具有口服活性的 ROCK1 抑制剂 (IC50=7 nM)。GSK-25 对 31 种激酶以及 RSK1 和 p70S6K 保持良好的选择性 (RSK1: IC50=398 nM, p70S6K: IC50=1 μM)。GSK-25 可抑制 P450 (CYP2C9、CYP2D6、CYP3A4的IC50 分别为2.5、5.2、2.5 μM)。 产品来源： https://www.medchemexpress.cn/gsk-25.html 研究领域：Cell Cycle/DNA Damage | Stem Cell/Wnt | Cytoskeleton | TGF-beta/Smad | MAPK/ERK Pathway 作用靶点：ROCK | Ribosomal S6 Kinase (RSK) In Vivo: GSK-25 (Rat aorta IC50=256 nM) is profiled in a spontaneously hypertensive rat (SHR) model of hypertension. At 30 mg/kg (p.o.), GSK-25 induces a 25 mmHg (t=3 hours) drop in blood pressure.? GSK-25 has promising oral bioavailability (49% in male Sprague-Dawley rats and 19% in monkey), good half-life (1.8 hours in rat and 2.2 hours in monkey). 相关产品：Covalent Screening Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | Stem Cell Signaling Compound Library | TGF-beta/Smad Compound Library | Anti-Aging Compound Library | Covalent Screening Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Anti-Cardiovascular Disease Compound Library | Cytoskeleton Compound Library | Orally Active Compound Library | Glutamine Metabolism Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Targeted Diversity Library | Cancer Stem Cells Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Serine/Threonine Kinase Inhibitor Library | Extracellular Vesicles (EVs) Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Y-27632 | Chroman 1 | Fasudil Hydrochloride | Belumosudil | BI-D1870 | Thiazovivin | Narciclasine | PF-4708671 | Carnosol | Afuresertib | GSK269962A | H-1152 dihydrochloride | GSK429286A | Quercitrin | Ripasudil | SM1-71 | LY-2584702 tosylate salt | LJH685 | Y-33075 | CCG-222740 | SL 0101-1 | AT13148 | Pentanoic acid | Sodium Salicylate | AT7867 | LJI308 | ROCK inhibitor-2 | M2698 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。