RHC 80267 产品活性：RHC 80267 (U-57908) 是一种有效的选择性二酰基甘油脂酶 (DAGL) 抑制剂 (对犬血小板的 IC50 为 4 μM)。RHC 80267 抑制胆碱酯酶活性，IC50 为 4 μM，从而增强了乙酰胆碱引起的松弛。RHC 80267 还抑制 COX 活性和磷脂酰胆碱的水解。 产品来源： https://www.medchemexpress.cn/rhc-80267.html 研究领域：Metabolic Enzyme/Protease | Neuronal Signaling | GPCR/G Protein | Immunology/Inflammation 作用靶点：Acyltransferase | mAChR | COX | Phospholipase In Vitro: The potentiation by RHC 80267 of the relaxation to acetylcholine could be caused by the inhibition of cholinesterase: (1) RHC 80267 does not affect the responses to carbachol, the carbamyl derivative of acetylcholine which only differs from acetylcholine by its resistance to hydrolysis by cholinesterase, and (2) the effect of RHC 80267 is mimicked by the inhibitor of cholinesterase neostigmine, RHC 80267 showing no additional effect in the presence of a maximally effective concentration of neostigmine. The determination of the effect of RHC 80267 on the cholinesterase activity of brain homogenate confirmed that RHC 80267 inhibits this enzyme in the same range of concentrations increasing the relaxation to acetylcholine, namely at 1-10 μM. In Vivo: RHC 80267 (40 μM) enhances contractions induced by U46619 (a thromboxane A2 analog) in human and rat pulmonary arteries (hPAs and rPAs, respectively) and by angiotensin II (ANG II) in rPAs in an endothelium-dependent manner. 相关产品：Bioactive Compound Library Plus | GW4869 | Clozapine N-oxide | Neomycin sulfate | Acetaminophen | OSMI-1 | Indomethacin | Deschloroclozapine | EIPA | Celecoxib | Pilocarpine Hydrochloride | U-73122 | Aspirin | Oxidopamine hydrobromide | A 922500 | Deferiprone | BAPTA | Avasimibe | Diclofenac | Atropine | PF-06424439 methanesulfonate | Gallic acid | Ibuprofen | OSMI-4 | Compound 48/80 trihydrochloride | Omeprazole | Catechin | T863 | 20(S)-Ginsenoside Rg3 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。