AC1903 产品活性：AC1903 是 TRPC5 的特异性选择性抑制剂，具有足细胞保护特性。AC1903 对 TRPC4 或 TRPC6 current 没有影响，并且在激酶谱分析中没有显示出脱靶效应。在局灶节段性肾小球硬化 (FSGS) 大鼠模型中，AC1903 抑制严重蛋白尿，并且防止足细胞丢失。 产品来源： https://www.medchemexpress.cn/ac1903.html 研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling 作用靶点：TRP Channel In Vitro: TRPC5 is a Ca2+ permeable nonselective cation channel highly expressed in brain and kidney.AC1903 (0-100 µM) blocks riluzole-activated TRPC5 whole-cell current, but fails to block carbachol (CCh)–induced TRPC4 and OAG-induced TRPC6 currents, even at high micromolar concentrations in Patch-clamp electrophysiology experiments. The ICIC50 values of ML204 (HY-12949) (IC50=13.6 μM) and AC1903 (IC50=14.7 μM) are nearly equipotent in human embryonic kidney 293 (HEK-293) cells expressing TRPC5. AC1903 (30 µM) inhibits angiotensin II-induced production of reactive oxygen species (ROS) in wild-type podocytes and podocytes expressing a mutant angiotensin II type 1 (AT1) receptor that cannot be inactivated and endocytosed.AC1903 (30 µM) blocks caAT1R-induced ROS generation. Increased podocyte cell death within 36 hours of caAT1R expression is observed, but AC1903  protects podocyte cells from cell death. In Vivo: AC1903 (intraperitoneal injection; 50 mg/kg; twice per day; 7 days) significantly suppresses proteinuria as well as reduces pseudocyst formation and podocyte loss in an AT1 receptor transgenic rat model of kidney disease.AC1903 (intraperitoneal injection; 50 mg/kg; twice per day; initiated on day 7 and treated for 1 week until day 14) initiatation on day 7 exhibits significant suppression of proteinuria with preserved podocyte numbers. Besides, AC1903 does not affect the mean arterial pressure (MAP) and exhibits no effect on body weight, blood urea nitrogen, or creatinine in Dahl S rats. 相关产品：Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | Mechanoreceptors Compound Library | Heterocyclic Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Ion Channel Compound Library | Bioactive Compound Library Max | Rosiglitazone | GsMTx4 | Capsaicin | EIPA | Probenecid | 2-Aminoethyl diphenylborinate | Diphenyleneiodonium chloride | Amiloride hydrochloride | GSK1016790A | Capsazepine | HC-067047 | HC-030031 | ML-SA1 | GSK2193874 | Resiniferatoxin | Adenosine 5′-diphosphoribose sodium | AMG9810 | ML-SA5 | Caffeic acid | SKF-96365 hydrochloride | GSK205 | BI-749327 | (-)-Menthol | ML-SI1 | Pregnenolone | Anandamide | Pico145 | Pyr3 | (1R,2R)-ML-SI3 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。