Afizagabar 产品活性：Afizagabar (S44819) 是一种首创的，有竞争性的，选择性的 α5-GABAAR 拮抗剂，对α5β2γ2 的IC50 值 585 nM，对 α5β3γ2 的 Ki 为 66 nM。Afizagabar 增强海马突触可塑性并显示促认知功效。 产品来源： https://www.medchemexpress.cn/afizagabar.html 研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling 作用靶点：GABA Receptor In Vitro: Afizagabar (S44819) is a competitive α5-GABAAR antagonist (Kb=221 nM). Afizagabar selectively inhibits extrasynaptic α5-GABAARs of mouse CA1 pyramidal neurons. In Vivo: Afizagabar (1 and 3 mg/kg; i.p.) significantly diminishes the marked increase in total errors induced by Scopolamine. 相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | Clinical Compound Library | Drug Repurposing Compound Library | Orally Active Compound Library | Neurotransmitter Receptor Compound Library | Anti-Alzheimer's Disease Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | GABA Receptor Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Ion Channel Compound Library | Bioactive Compound Library Max | Bicuculline | γ-Aminobutyric acid | Picrotoxin | Aminooxyacetic acid hemihydrochloride | Propofol | Riluzole | Furosemide | Gabazine | Baclofen | Amentoflavone | Vigabatrin | CGP52432 | Flumazenil | Methionine | Jujuboside A | L-Cycloserine | Etiocholanolone | THIP | Topiramate | Broflanilide | Tiagabine hydrochloride | Muscimol | Clomethiazole | (S)-SNAP5114 | Dihydroergotoxine mesylate | Emamectin Benzoate | Ginkgolide A 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。