UCB-9260 产品活性：UCB-9260 是一种口服活性小分子，通过稳定三聚体的不对称形式抑制肿瘤坏死因子 (TNF) 信号传导。UCB-9260 对肿瘤坏死因子的选择性高于其他超家族成员，并与肿瘤坏死因子结合，其 Kd 值为 13 nM。 产品来源： https://www.medchemexpress.cn/ucb-9260.html 研究领域：Apoptosis 作用靶点：TNF Receptor In Vitro: UCB-9260 (0-10 μM)?inhibits NF-κB with a geometric mean IC50?of 202 nM after TNF (10 pM) stimulation in in Hek-293 cells.? UCB-9260?inhibits TNF-dependent cytotoxicity with a geometric mean IC50?of 116 nM and a geometric mean IC50?of 120 nM, using human and mouse TNF, respectively. In Vivo: UCB-9260 (150?mg/kg; p.o.;twice daily?for 7 days) shows a significant reduction of the clinical score.? UCB-9260?(10-300?mg/kg; p.o.) dose-dependently inhibits human and mouse TNF-induced neutrophil recruitment to the peritoneal compartment in adult male Balb/c mice. 相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | Differentiation Inducing Compound Library | Angiogenesis-Related Compound Library | Antidepressant Compound Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Heterocyclic Compound Library | Mitochondrial Protection Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Autoimmune Disease Compound Library | Highly Selective Inhibitors Library | Cytokine Inhibitors Library | Radioprotector Library | Bioactive Compound Library Max | Resatorvid | Shikonin | Infliximab | Fisetin | Adalimumab | Etanercept | N-Formyl-Met-Leu-Phe | Apremilast | R-7050 | Theophylline | QNZ | Nafamostat mesylate | C25-140 | Diprovocim | Brentuximab vedotin | Muscone | Certolizumab pegol | Forsythoside B | TRAF-STOP inhibitor 6877002 | Astilbin | Sinensetin | Belimumab | Geraniin | HS-276 | Adalimumab (anti-TNF-α) | Semapimod tetrahydrochloride | Mulberroside A | TNF-α (31-45), human | TNF-α-IN-2 | DRI-C21045 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。