α-Synuclein inhibitor 8 产品活性：α-Synuclein inhibitor 8 是一种有效的 α-Synuclein 抑制剂，IC50 值为 2.5 µM。α-Synuclein inhibitor 8 对 α-Synuclein 纤维的聚集和解聚具有高度抑制作用。α-Synuclein inhibitor 8 减少了神经元细胞中内含物的形成，能修复受损的神经元并改善帕金森病 (PD) 样症状。α-Synuclein inhibitor 8 具有高抗氧化性和低细胞毒性。 产品来源： https://www.medchemexpress.cn/α-synuclein-inhibitor-8.html 研究领域：Neuronal Signaling 作用靶点：α-synuclein In Vitro: α-Synuclein inhibitor 8 (Compound 2ee) (0-100 μM; 0-96 h) inhibits the aggregation of α-Synuclein in a dose-dependent manner. α-Synuclein inhibitor 8 (100 µM; 48 h) decomposes mature fiber into soluble protein and a small amount of short insoluble fiber. α-Synuclein inhibitor 8 (1-1000 µM; 0.5 h or 24 h) increases the clearance rate of reactive oxygen species in a dose-dependent manner. α-Synuclein inhibitor 8 has low cytotoxicity to H4 and SH-SY5Y cells (cell viability is higher than 80%). α-Synuclein inhibitor 8 (10 µM; 38 h) has inhibitory effect on α-Synuclein aggregation and inclusion body formation in H4 cells. In Vivo: α-Synuclein inhibitor 8 (Compound 2ee) (0.9 μg/μL; i.v.; single dose) significantly improves Parkinson’s disease (PD)-like symptoms such as weak grip, limb stiffness and poor balance in C57 mice model of PD. α-Synuclein inhibitor 8 has neuroprotective effect on the middle caudate putamen (CPU) and substantia nigra reticular (SNr) of the brain in C57 mice model of PD. 相关产品：Utreloxastat | Buntanetap | SynuClean-D | PBT434 mesylate | ELN484228 | Minzasolmin | PROTAC α-synuclein degrader 3 | PROTAC α-synuclein degrader 5 | α-Synuclein (61-75) (TFA) | Cinpanemab | Prasinezumab | tau protein/α-synuclein-IN-1 | α-Synuclein (61-95) (human) | Brazilin-7-acetate | D-685 | MAO-B-IN-31 | Peucedanocoumarin III | PROTAC α-synuclein degrader 6 | Sycosterol A | α-Synuclein (34-45) (human) | α-Synuclein (45-54) (human) | α-Synuclein (67-78) (human) | α-Synuclein (71-82) (human) | α-Synuclein 4554W | α-Synuclein inhibitor 10 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。