DSM502 产品活性：DSM502 是一种基于吡咯的二氢乳清酸脱氢酶 (DHODH) 抑制剂。DSM502 对 Plasmodium DHODH 和 Plasmodium 寄生虫表现出纳摩尔级效力，对哺乳动物 DHODH 没有抑制作用。 产品来源： https://www.medchemexpress.cn/dsm502.html 研究领域：Metabolic Enzyme/Protease | Anti-infection 作用靶点：Dihydroorotate Dehydrogenase | Parasite In Vitro: DSM502 shows inhibitory activity against P. falciparum DHODH (PfDHODH, IC50=20 nM), P. vivax DHODH (PvDHODH, IC50=14 nM) and Pf3D7 cells (EC50=14 nM), with no inhibition of the human enzyme. In Vivo: DSM502 (10 and 50 mg/kg; p.o. once daily for 4 days) results in 97% parasite clearance in confirmatory SCID study compared to 85% clearance in the GSK study. DSM502 (18.3 and 50 mg/kg; a single p.o.) exhibits high oral bioavailability (>100%, >100%), apparent t1/2 (2.6, 3.6 h) and Cmax (8.4, 42.3 μM) in mice. DSM502 (2.8 mg/kg; a single i.v.) exhibits apparent t1/2 (2.8 h), plasma clearance (26.1 mL/min/kg), and Vss (1.2 L/kg) in mice. 相关产品：Bioactive Compound Library Plus | Anti-Infection Compound Library | Metabolism/Protease Compound Library | Ferroptosis Compound Library | Orally Active Compound Library | Antiparasitic Compound library | Mitochondria-Targeted Compound Library | Heterocyclic Compound Library | Metabolic Enzyme Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Chloroquine | Puromycin dihydrochloride | Hygromycin B | Doxycycline hyclate | Acetaminophen | Anisomycin | Metronidazole | Kaempferol | Amphotericin B | Hydroxychloroquine | Brequinar | Monensin sodium | Dihydroartemisinin | Niclosamide | Berberine chloride | Artesunate | Acridine Orange hydrochloride | Ivermectin | Eflornithine hydrochloride hydrate | Azithromycin | TPE-MI | Halofuginone | Ibuprofen | Artemisinin | 5'-Methylthioadenosine | Leflunomide | RRx-001 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。