F 13714 fumarate 产品活性：F13714 fumarate 是一种选择性 5-HT1A 受体偏向激动剂，在慢性轻度应激小鼠模型中单次给药后具有抗抑郁样特性。 产品来源： https://www.medchemexpress.cn/f13714-fumarate.html 研究领域：GPCR/G Protein | Neuronal Signaling 作用靶点：5-HT Receptor In Vitro: F13714 targets 5-HT1A autoreceptors. In Vivo: In UCMS mice, a single administration of F13714 (4–16 mg/kg) is sufficient to robustly normalize depressive-like behavior in the forced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels. F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5%. F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement. F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in naïve rats. 相关产品：Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | Neurotransmitter Receptor Compound Library | Anti-Alzheimer's Disease Compound Library | Anti-Obesity Compound Library | Targeted Diversity Library | Antidepressant Compound Library | 5-HT Receptor Compound Library | Coagulation and Anti-coagulation Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Activators Library | Bioactive Compound Library Max | Chlorpromazine hydrochloride | Serotonin hydrochloride | SCH-23390 hydrochloride | Harmine | Puerarin | PNU-282987 | Scopolamine hydrobromide | Clozapine | Risperidone | Vortioxetine | Olanzapine | Dihydroergotamine mesylate | Aripiprazole | GTS-21 dihydrochloride | Amitriptyline hydrochloride | Ondansetron | Thioridazine hydrochloride | Brexpiprazole | SB-269970 hydrochloride | Cisapride | SEP-363856 hydrochloride | Volinanserin | Vilazodone Hydrochloride | Pimavanserin | 8-OH-DPAT | Ketanserin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。