Pesampator 产品活性：Pesampator (PF-04958242) 是一种有效的、高选择性的 AMPA 受体的正变构调节剂 (AMPA 增强剂)，EC50 为 310 nM，Ki 为 170 nM。 产品来源： https://www.medchemexpress.cn/pesampator.html 研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling 作用靶点：iGluR In Vivo: Pesampator (0.1-1 mg/kg; SC) dose-dependently increases CD-1 mouse cerebellum cGMP and Pesampator (0.1-0.32 mg/kg; SC) decreases fall latency in C57BL/6J mice traversing an accelerating rotarod.? Pesampator (0.001-0.01 mg/kg; male Sprague-Dawley rats) reverses the MK-801-mediated (0.05 mg/kg; IV) reduction in paired-pulse facilitation (PPF) after cumulative or a single (0.01 mg/kg) intravenous dose.? Pesampator (0.0032–0.032 mg/kg; SC) attenuates ketamine-induced working memory disruptions in rats as determined by mean errors in a radial arm maze.? In rats, Pesampator (0.027, 0.08, and 0.60 mg/kg; SC) dose-dependently affectes the regional brain uptake of 2-deoxy-2-[18F]fluoro-d-glucose (FDG). 相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | Clinical Compound Library | Drug Repurposing Compound Library | Neurotransmitter Receptor Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Activators Library | Ion Channel Compound Library | Allosteric Modulators (AMs) Compound Library | Bioactive Compound Library Max | Corticosterone | Dizocilpine maleate | D-AP5 | NMDA | L-Glutamic acid | Evans Blue | CNQX | Kynurenic acid | Glycine | L-Phenylalanine | NBQX | Quinolinic acid | Cycloleucine | Ifenprodil tartrate | Memantine hydrochloride | D-Cycloserine | DNQX | Ro 25-6981 Maleate | (-)-Huperzine A | Naspm trihydrochloride | Ibotenic acid | 24-Hydroxycholesterol | Crocetin | Decanoic acid | Bupivacaine | Topiramate | Tacrine hydrochloride 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。