ML381 产品活性：ML381 (VU0488130) 是一种高选择性、中枢神经系统渗透性的 mAChR M5 正交拮抗剂 (IC50 = 450 nM; Ki = 340 nM)。ML381 在大鼠血浆中不稳定，可主要用作体外和电生理研究的分子探针。 产品来源： https://www.medchemexpress.cn/ml381.html 研究领域：GPCR/G Protein | Neuronal Signaling 作用靶点：mAChR In Vivo: ML381 (0.2 mg/kg; i.v.; single) possesses an overall acceptable DMPK profile for pharmacodynamic studies in rat, with the exception of poor metabolic stability and a potential for amide hydrolysis in plasma; as such, ML381 is best suited to use as an in vitro/electrophysiological probe. 相关产品：Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | CNS-Penetrant Compound Library | Neurotransmitter Receptor Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Bioactive Compound Library Max | Clozapine N-oxide | Deschloroclozapine | Pilocarpine Hydrochloride | Atropine | Scopolamine hydrobromide | Carbamoylcholine chloride | Olanzapine | Amitriptyline hydrochloride | Methacholine chloride | Xanomeline | Mepenzolate bromide | (S)-(+)-Dimethindene maleate | Promethazine hydrochloride | Propantheline bromide | Benztropine mesylate | Oxotremorine M iodide | Arecoline hydrobromide | Darifenacin hydrobromide | Tiotropium Bromide | DREADD agonist 21 | Pirenzepine dihydrochloride | Dronedarone 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。