MC1568
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分子量314.31 属性 溶解性 DMSO 13 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 存贮条件 储存温度-20°C //decorateTable('product-attribute-s
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| 货号 | CAS号 | 操作 |
|---|---|---|
| M127417-25mg | 852475-26-4 | 询底价 |
| M127417-10mg | 852475-26-4 | 询底价 |
耗材描述
- 分子量314.31
属性
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 产品介绍 | MC1568 |
| 备注 | MC1568 is a selective HDAC inhibitor for HDAC1A with IC50 of 100 nM. It is 34-fold more selective for HDAC1A than HDAC1B. |
| 生化机理 |
MC1568 is a class II (IIa) histone deacetylase (HDAC) inhibitor selective for HDAC4 and HDAC6 (IC50 = 220 nM). MC1568 exhibits tissue-selective inhibition between members of class II acetylases in vivo, particularly in skeletal muscle and the heart. MC1568 arrests myogenesis through the stabilization of myocyte enhancer factor 2D (MEF2D)-HDAC3/4 complex. Recent research showed that class II-specific HDACis may constitute a novel therapeutic strategy for improving the treatment of cancer. |
| 别名 | (E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide;(E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide |
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