Trichostatin A

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：3
近期咨询：1

分子式 C17H22N2O3 分子量302.37 MDL号 MFCD03848392 PubChem编号 24900542 属性敏感性对热敏感溶解性 Soluble in water (Partly Miscible), ethano

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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配套的仪器设备？可以搭配的相关耗材试剂？

货号	CAS号	操作
T129665-5mg	58880-19-6	询底价
T129665-10mg	58880-19-6	询底价
T129665-50mg	58880-19-6	询底价

耗材描述

分子式 C₁₇H₂₂N₂O₃
分子量302.37
MDL号 MFCD03848392
PubChem编号 24900542

属性

敏感性	对热敏感
溶解性	Soluble in water (Partly Miscible), ethanol (2 mg/mL), DMSO (20 mg/mL), acetonitrile, DMF (30 mg/mL), and methanol
存贮条件	储存温度-20°C

描述

应用	A potent and non-competitive reversible inhibitor of HDAC.
产品介绍	Trichostatin A (TSA)是一种HDAC抑制剂，IC50为1.8 nM左右，HDAC8是HDAC家族中唯一不受TSA影响的成员。
备注	Trichostatin A (TSA) is an HDAC inhibitor with IC50 of ~1.8 nM – HDAC8 is the only known member of the HDAC-family that is not affected by TSA. Phase 3.
生化机理	Trichostatin A (TSA) is a potent and non-competitive reversible inhibitor of histone deacetylases (HDAC) with a Ki of 3.4 nM. In HeLa cells, TSA blocked cell cycle progression at G1 and induced a 12-fold increase in intracellular levels of gelsolin. In cells latently infected with HIV-1, TSA induced the transcriptional activation of the HIV-1 promoter, which resulted in a marked increase in virus production. In NIH 3T3 cells, TSA induced reversion of oncogenic ras-transformed cells to a normal morphology. In Jurkat cells, TSA inhibited IL-2 gene expression and displayed immunosuppressive activity in a mouse model. Induces increased acetylation of GATA4, a cardiac-specific transcription factor and increases cardiac muscle cell differentiation. In normal fibroblasts, induced Friend cell differentiation and inhibited the G1 and G2 phases of the cell cycle.
别名	TSA;曲古抑菌素 A;曲古柳菌素A ;TSA; R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

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