Nafamostat Mesylate
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分子式 C19H17N5O2·2CH4O3S 分子量539.58 Beilstein号 EC号 MDL号 MFCD00941430 PubChem编号 属性 熔点 260 °C 溶解性 Soluble in DMSO (>10 mg/
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| 货号 | CAS号 | 操作 |
|---|---|---|
| N129262-10mg | 82956-11-4 | 询底价 |
| N129262-250mg | 82956-11-4 | 询底价 |
| N129262-50mg | 82956-11-4 | 询底价 |
耗材描述
- 分子式 C19H17N5O2·2CH4O3S
- 分子量539.58
- Beilstein号
- EC号
- MDL号 MFCD00941430
- PubChem编号
属性
| 熔点 | 260 °C |
| 溶解性 | Soluble in DMSO (>10 mg/ml), water (25 mg/ml) Note: Phosphate-containing buffers may cause precipitation, and ethanol (<1 mg/mL) at 25 °C. |
| 存贮条件 | 储存温度 2-8°C |
描述
| 应用 | A highly effective tryptase inhibitor. |
| 产品介绍 | Nafamostat Mesylate是一种抗凝血剂。 |
| 备注 | Nafamostat Mesylate is an anticoagulant. |
| 生化机理 | Nafamostat mesylate is a highly effective tryptase (Ki=95.3 pM) inhibitor. The compound has the ability to promote synthesis of interferon-γ, tumor necrosis factor-α, IL-12, and IL-18. Additionally, Nafamostat mesylate can induce production of intercellular adhesion molecules-1, B7.1, B7.2, CD40 and CD40 ligand in human blood mononuclear cells. Nafamostat mesylate is an anticoagulant and has been shown to decrease levels of plasma myeloperoxidase, and has also been used in ERCP pancreatitis studies. Nafamostat mesylate is an inhibitor of Factor X, Factor XII, granzyme A and KLK. |
| 别名 | 萘莫司他甲磺酸盐;甲磺酸萘莫司他; FUT-175;6-脒基-2-萘基 4-胍基苯甲酸酯甲基磺酸盐;Coahibitor; FUT-175; Futhan;6-Amidino-2-naphthyl 4-Guanidinobenzoate Bis(methanesulfonate);4-Guanidinobenzoic Acid 6-Amidino-2-naphthyl Ester Bis(methanesulfonate) |
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