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分子式 H6Cl2N2Pt 分子量300.1 Beilstein号 EC号 MDL号 MFCD00011623 PubChem编号 属性 熔点 270°C 敏感性 对湿度敏感&对光敏感 溶解性 Soluble in DMSO (25 mg/
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| 货号 | CAS号 | 价格 | 操作 |
|---|---|---|---|
| D109812-1g | 15663-27-1 | ￥999.00 | 询底价 |
| D109812-250mg | 15663-27-1 | ￥449.00 | 询底价 |
| D109812-5g | 15663-27-1 | ￥3,949.00 | 询底价 |
耗材描述
- 分子式 H6Cl2N2Pt
- 分子量300.1
- Beilstein号
- EC号
- MDL号 MFCD00011623
- PubChem编号
属性
| 熔点 | 270°C |
| 敏感性 | 对湿度敏感&对光敏感 |
| 溶解性 | Soluble in DMSO (25 mg/ml), water (0.25 g/100ml) at 25 °C, ethanol (<1 mg/ml) at 25 °C, and DMF (16 mg/ml) |
| 存贮条件 | 充氩保存 |
| 密度 | 3.7000 |
描述
| 应用 |
cis-Diamineplatinum(II) dichloride can be used as a model drug to test the efficiency of various drug carriers in drug delivery. cis-Diammineplatinum(II) dichloride has been used: · in cell viability measurement in cochlear explants · in the inhibition of cell proliferation and chemosensitivity in ovarian cancer cell lines · in MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] cell viability assay in oral squamous cell carcinoma |
| 产品介绍 | 微溶于水，易溶于二甲基甲酰胺。在水溶液中可逐渐转化成反式和水解。 |
| 生化机理 | Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links. Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca2+/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks. Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links. |
| 别名 | 顺双氯双氨络铂，氯氨铂，顺二氯二氨基铂;顺式-二胺二氯铂;顺-二胺二氯铂(II);顺氯氨铂;cis-Dichlorodiammine platinum(II); cis-Platinum(II) diammine dichloride; cis-Diammineplatinum(II) dichloride ; Cisplatin |
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