Product Introduction
Bioactivity


英文名: Methazolamide

描述: Methazolamide (CL 8490) 是一种磺胺衍生物，用作碳酸酐酶 (carbonic anhydrase) 抑制剂，对人 carbonic anhydrase II 的 Ki=为 14 nM。它是降低眼压的药物，能够抑制由青光眼及其他眼病引起的眼压升高的作用。

体外活性: 在麻醉的兔子体内,Methazolamide不损害呼吸功能.

体内活性: Methazolamide是一种碳酸酐酶抑制剂,可抑制hCA I（Ki：50 nM）,hCA II（Ki：14 nM）和bCA IV（Ki：36 nM）亚型。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 60 mg/mL (253.95 mM)
Ethanol : 3 mg/mL (12.69 mM)


关键字: pressure-lowering | Carbonate dehydratase | Carbonic Anhydrase | glaucoma | disorders | L 584601 | intraocular | Inhibitor | CL-8490 | Methazolamide | CL8490 | inhibit | L-584601

相关产品: Zonisamide | Girentuximab | U-104 | CA inhibitor 2 | Cyclamic acid sodium | Methyl 2,4-dihydroxybenzoate | ALP/Carbonic anhydrase-IN-1 | Taselisib | Enpp/Carbonic anhydrase-IN-2 | Indisulam

相关库: Anti-Aging Compound Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Diabetic Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Approved Drug Library | Preclinical Compound Library | NO PAINS Compound Library