Product Introduction
Bioactivity


英文名: Rocuronium bromide

描述: Rocuronium bromide (ORG 9426) 是一种氨基甾体类的、非去极化的神经肌肉受体抑制剂，也是一种肌肉松弛剂。

体外活性: Rocuronium bromide 以浓度依赖性方式降低了正常（IC50：9.84 μM）和所有预处理膈肌（P < .01，n = 6）的间接诱发抽搐张力[1]。Rocuronium bromide 的 ED95 对儿童和成人基本相同。常规剂量的胆碱酯酶抑制药物很容易逆转Rocuronium bromide 的作用[2]。Rocuronium bromide 的最大阻滞前的起效时间、抽搐高度恢复 25% 前的持续时间以及抽搐高度恢复 25% 至 75% 前的持续时间分别为 1.7（32）、53（19）和 20（37）分钟[3]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 113 mg/mL (185.3 mM)
H2O : 112 mg/mL (183.7 mM)
Ethanol : 113 mg/mL (185.3 mM)


关键字: Rocuronium Bromide | Rocuronium | ORG9426 | ORG-9426 | Inhibitor | inhibit | Rocuronium bromide

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