Product Introduction
Bioactivity


英文名: Azacyclonol

描述: Azacyclonol (MER 17) 是一种中枢神经系统抑制剂，是 Terfenadine 的代谢产物。它是神经节阻滞剂，可用于减少精神病引起的幻觉。

体外活性: Azacyclonol抑制猫颈上神经节传输的活性为6.63％.静脉注射Azacyclonol可以影响瞬膜对节后和节前刺激的反应.

体内活性: Azacyclonol作用于人体肝脏微粒体的表观Km和Vmax 值分别为 0.82 μM 和 60 pmol/min/mg。Azacyclonol 在人体肠道微粒体中形成,与时间呈线性相关,长达60分钟。微粒体蛋白浓度达2 mg/mL时Azacyclonol的形成率线性增强。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 49 mg/mL (183.3 mM)
H2O : 2 mg/mL (7.48 mM)
DMSO : 49 mg/mL (183.3 mM)


关键字: Azacyclonol | hallucinations | Inhibitor | depressant | Terfenadine | psychoses | MER17 | central | MDL4829 | MER-17 | inhibit | MDL-4829 | gamma-pipradol | r-pipradol | Histamine Receptor

相关产品: SB-269970 hydrochloride | 5-HT3 antagonist 3 | SB 258585 | Itasetron | RS-127445 hydrochloride | BMY-14802 hydrochloride | Nexopamil racemate | Org 13011 | Jujuboside B1 | FFN246

相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | ReFRAME Related Library | Drug-Fragment Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Inhibitor Library | Anti-Obesity Compound Library | NO PAINS Compound Library