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Product IntroductionBioactivity英文名: Colchicine描述: Colchicine (Colcin) 属于天然产物，是一种微管聚合的抑制剂 (IC50=3 nM)，通过与微管蛋白结合来阻断微管的聚合。Co
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Product Introduction
Bioactivity
英文名: Colchicine
描述: Colchicine (Colcin) 属于天然产物，是一种微管聚合的抑制剂 (IC50=3 nM)，通过与微管蛋白结合来阻断微管的聚合。Colchicine 可以被用于治疗通风和风湿病。
动物实验: a C57BL/6 background are used. To examine the effects of Colchicine on NSAID-induced small intestinal injury, vehicle or Colchicine (1 or 3 mg/kg) is administered orally 30 min prior to indomethacin administration. Mice received intraperitoneal injections of sterilized phosphate buffered saline or mouse recombinant IL-1β (0.1 μg/kg) 3 h after indomethacin treatment. Vehicle or Colchicine (1 or 3 mg/kg) is also administered to NLRP3?/? mice before indomethacin administration. The lesion index is evaluated 24 h after indomethacin administration and examined mRNA and protein expression of inflammasome components 6 h after indomethacin administration.
体外活性: 方法：人咽癌细胞 FaDu 和 SNU1041 用 Colchicine (0.0-1 μM) 处理 24-72 h，使用 XTT assay 检测细胞活力。结果：Colchicine 处理以剂量和时间依赖的方式对 FaDu 和 SNU1041 细胞系都具有细胞毒性作用。[1]方法：绒毛膜细胞 AFCs 和羊水细胞 CVCs 用 Colchicine (0.15 μg/mL) 处理 3-24 h，使用 Flow Cytometry 检测细胞凋亡情况。结果：Colchicine 诱导 annexin V 和 PI 双阳性细胞的比例显著增加。[2]
体内活性: 方法：为研究抗肿瘤活性，将 Colchicine (0.1 mg/kg) 口服给药给携带人咽癌肿瘤 FaDu 的 BALB/c-nu 小鼠，每两天一次，持续十四天。结果：Colchicine 在下咽癌症模型裸鼠中有效抑制肿瘤生长，而没有严重并发症。[1]方法：为研究对抗 Fas 抗体诱导的致死性的影响，将 Colchicine (2 mg/kg) 腹腔注射给 C57BL/6 小鼠，24 h 后注射 Jo2 抗体 (10 μg)。结果：所有用 Colchicine 处理的小鼠都在致命的攻击中存活下来。Colchicine 降低了小鼠对抗 Fas 抗体 Jo2 致死作用的易感性。[3]
存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 45 mg/mL (112.66 mM)
H2O : 1.33 mg/mL(3.34 mM)
关键字: Autophagy | inhibit | Microtubule/Tubulin | Apoptosis | Colchicine | Inhibitor
相关产品: Sulfasalazine | PP5-IN-1 | α-Tocopherol phosphate disodium | OTS964 hydrochloride | BAY1082439 | Niraparib hydrochloride | RIPGBM | DPN | Gemcitabine elaidate | HBDDE
相关库: Drug Repurposing Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Microtubule-Targeted Compound Library | Anti-Cancer Drug Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Approved Drug Library | Autophagy Compound Library | RO5 Drug-like Natural Product Library
Bioactivity
英文名: Colchicine
描述: Colchicine (Colcin) 属于天然产物，是一种微管聚合的抑制剂 (IC50=3 nM)，通过与微管蛋白结合来阻断微管的聚合。Colchicine 可以被用于治疗通风和风湿病。
动物实验: a C57BL/6 background are used. To examine the effects of Colchicine on NSAID-induced small intestinal injury, vehicle or Colchicine (1 or 3 mg/kg) is administered orally 30 min prior to indomethacin administration. Mice received intraperitoneal injections of sterilized phosphate buffered saline or mouse recombinant IL-1β (0.1 μg/kg) 3 h after indomethacin treatment. Vehicle or Colchicine (1 or 3 mg/kg) is also administered to NLRP3?/? mice before indomethacin administration. The lesion index is evaluated 24 h after indomethacin administration and examined mRNA and protein expression of inflammasome components 6 h after indomethacin administration.
体外活性: 方法：人咽癌细胞 FaDu 和 SNU1041 用 Colchicine (0.0-1 μM) 处理 24-72 h，使用 XTT assay 检测细胞活力。结果：Colchicine 处理以剂量和时间依赖的方式对 FaDu 和 SNU1041 细胞系都具有细胞毒性作用。[1]方法：绒毛膜细胞 AFCs 和羊水细胞 CVCs 用 Colchicine (0.15 μg/mL) 处理 3-24 h，使用 Flow Cytometry 检测细胞凋亡情况。结果：Colchicine 诱导 annexin V 和 PI 双阳性细胞的比例显著增加。[2]
体内活性: 方法：为研究抗肿瘤活性，将 Colchicine (0.1 mg/kg) 口服给药给携带人咽癌肿瘤 FaDu 的 BALB/c-nu 小鼠，每两天一次，持续十四天。结果：Colchicine 在下咽癌症模型裸鼠中有效抑制肿瘤生长，而没有严重并发症。[1]方法：为研究对抗 Fas 抗体诱导的致死性的影响，将 Colchicine (2 mg/kg) 腹腔注射给 C57BL/6 小鼠，24 h 后注射 Jo2 抗体 (10 μg)。结果：所有用 Colchicine 处理的小鼠都在致命的攻击中存活下来。Colchicine 降低了小鼠对抗 Fas 抗体 Jo2 致死作用的易感性。[3]
存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 45 mg/mL (112.66 mM)
H2O : 1.33 mg/mL(3.34 mM)
关键字: Autophagy | inhibit | Microtubule/Tubulin | Apoptosis | Colchicine | Inhibitor
相关产品: Sulfasalazine | PP5-IN-1 | α-Tocopherol phosphate disodium | OTS964 hydrochloride | BAY1082439 | Niraparib hydrochloride | RIPGBM | DPN | Gemcitabine elaidate | HBDDE
相关库: Drug Repurposing Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Microtubule-Targeted Compound Library | Anti-Cancer Drug Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Approved Drug Library | Autophagy Compound Library | RO5 Drug-like Natural Product Library
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