化合物 T10211 T10211
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Product IntroductionBioactivity英文名: Aβ42-IN-1描述: Aβ42-IN-1，化合物 1v，是一种新型有效且具有口服活性的 γ 分泌酶调节剂 (GSM)。 Aβ42-IN-1 在不抑制 CYP3A4 的
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Product Introduction
Bioactivity
英文名: Aβ42-IN-1
描述: Aβ42-IN-1，化合物 1v，是一种新型有效且具有口服活性的 γ 分泌酶调节剂 (GSM)。 Aβ42-IN-1 在不抑制 CYP3A4 的情况下，在培养细胞中有效降低Aβ42水平，IC50值为 0.091 μM。Aβ42-IN-1 显示出良好的药代动力学特征。
体内活性: Aβ42-IN-1 (orally adminstation; 30 mg/kg) demonstrates a good pharmacokinetic profile in mice, significantly reduces Aβ42 levels in the brain and plasma, by 36% and 66%, respectively. while the brain/plasma ratio of 1v is slightly lower than that of 1a [1]. Animal Model: 8- week-old male ddY mice Dosage: 30 mg/kg Administration: Orally adminstation; 30 mg/kg Result: Reduced Aβ42 levels in the brain and plasma, by 36% and 66%, respectively.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Aβ42IN1 | Aβ42-IN-1 | Ab42-IN-1 | Abeta42-IN-1 | Aβ42 IN 1
Bioactivity
英文名: Aβ42-IN-1
描述: Aβ42-IN-1，化合物 1v，是一种新型有效且具有口服活性的 γ 分泌酶调节剂 (GSM)。 Aβ42-IN-1 在不抑制 CYP3A4 的情况下，在培养细胞中有效降低Aβ42水平，IC50值为 0.091 μM。Aβ42-IN-1 显示出良好的药代动力学特征。
体内活性: Aβ42-IN-1 (orally adminstation; 30 mg/kg) demonstrates a good pharmacokinetic profile in mice, significantly reduces Aβ42 levels in the brain and plasma, by 36% and 66%, respectively. while the brain/plasma ratio of 1v is slightly lower than that of 1a [1]. Animal Model: 8- week-old male ddY mice Dosage: 30 mg/kg Administration: Orally adminstation; 30 mg/kg Result: Reduced Aβ42 levels in the brain and plasma, by 36% and 66%, respectively.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Aβ42IN1 | Aβ42-IN-1 | Ab42-IN-1 | Abeta42-IN-1 | Aβ42 IN 1
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