Product Introduction
Bioactivity


英文名: AAPK-25

描述: AAPK-25 是选择性的Aurora/PLK 激酶双重抑制剂，显示出抗肿瘤活性。它可造成有丝分裂延迟并阻滞前中期细胞，通过生物标志物组蛋白 H3Ser10磷酸化反应，导致细胞凋亡激增。

体外活性: AAPK-25抑制HCT-116、Calu6、A549和MCF-7细胞增长(IC50s分别为0.4、5.3、11.6和2.3 μM)。在HCT-116细胞系中，AAPK-25按剂量依赖性诱导凋亡。AAPK-25显著增加组蛋白H3Ser10的磷酸化，表明明显的有丝分裂阻塞。AAPK-25对有丝分裂纺锤体检查点具有显著抑制作用。

体内活性: AAPK-25在BALB/c裸鼠肿瘤异种移植模型中提高了存活率。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (113.04 mM)


关键字: Aurora Kinase | AAPK 25 | inhibit | Polo-like Kinase (PLK) | AAPK25 | Apoptosis | Inhibitor | AAPK-25

相关产品: 1,4-Dideoxy-1,4-epithio-D-ribitol | XL019 | Salermide | ICCB-19 hydrochloride | Ac-Pro-Gly-Pro-OH | Casein Kinase inhibitor A51 | BIBR 1532 | Isolongifolene | Onatasertib | SU9516

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Epigenetics Compound Library | Anti-Cancer Active Compound Library | Bioactive Compound Library