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Product IntroductionBioactivity英文名: AE-3763描述: AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 n
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Product Introduction
Bioactivity
英文名: AE-3763
描述: AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).
动物实验: D-Galactosamine shock is induced in C3H/HeN mice (6-7 w, 22-25 g). AE-3763 (10 or 100 mg/kg) is administrated intraperitoneally six times at 2 h interval. Control animals receive the vehicle (PBS) instead of AE-3763. The animal survival rate is observed up to 24 h after shock induction.
体外活性: AE-3763 has potent inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water.
体内活性: Edema and leukocytes infiltration into the lung is significantly inhibited by the infusion of AE-3763. AE3763 significantly improves survival rate by 24 h in a mouse model of fatal shock associated with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when given intravenously by infusion (ED50: 0.42 mg/kg/h) or by bolus injection (1.2 mg/kg). With regard to the toxicity of AE-3763 (300 mg/kg, i.v.) in mice, the results of a preliminary study have shown no overt toxic effect.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: AE 3763 | AE-3763 | AE3763
相关产品: ZM223 hydrochloride (2031177-48-5 free base) | BCX 1470 hydrochloride | Diminazene Aceturate | 2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE | Sivelestat | PMSF | BMS-363131 | BCX 1470 | Upamostat | SC-514
Bioactivity
英文名: AE-3763
描述: AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).
动物实验: D-Galactosamine shock is induced in C3H/HeN mice (6-7 w, 22-25 g). AE-3763 (10 or 100 mg/kg) is administrated intraperitoneally six times at 2 h interval. Control animals receive the vehicle (PBS) instead of AE-3763. The animal survival rate is observed up to 24 h after shock induction.
体外活性: AE-3763 has potent inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water.
体内活性: Edema and leukocytes infiltration into the lung is significantly inhibited by the infusion of AE-3763. AE3763 significantly improves survival rate by 24 h in a mouse model of fatal shock associated with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when given intravenously by infusion (ED50: 0.42 mg/kg/h) or by bolus injection (1.2 mg/kg). With regard to the toxicity of AE-3763 (300 mg/kg, i.v.) in mice, the results of a preliminary study have shown no overt toxic effect.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: AE 3763 | AE-3763 | AE3763
相关产品: ZM223 hydrochloride (2031177-48-5 free base) | BCX 1470 hydrochloride | Diminazene Aceturate | 2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE | Sivelestat | PMSF | BMS-363131 | BCX 1470 | Upamostat | SC-514
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