化合物 T10523 T10523
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Product IntroductionBioactivity英文名: β3-AR agonist 1描述: β3-AR agonist 1 is a highly selective, and orally available agonis
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Product Introduction
Bioactivity
英文名: β3-AR agonist 1
描述: β3-AR agonist 1 is a highly selective, and orally available agonist of β3-adrenergic receptor (EC50: 18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold).
体内活性: In marmoset urinary bladder smooth muscle, β3-AR agonist 1 (compound 15) has dose-dependent β3-AR-mediated responses. It has desirable metabolic stability and pharmacokinetic profile (Cmax and AUC), and do not obviously affect heart rate or mean blood pressure when administered intravenously (3 mg/kg) to anesthetized rats.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: β3 AR agonist 1 | β3AR agonist 1 | β3-AR agonist 1 | b3-AR agonist 1 | beta3-AR agonist 1
Bioactivity
英文名: β3-AR agonist 1
描述: β3-AR agonist 1 is a highly selective, and orally available agonist of β3-adrenergic receptor (EC50: 18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold).
体内活性: In marmoset urinary bladder smooth muscle, β3-AR agonist 1 (compound 15) has dose-dependent β3-AR-mediated responses. It has desirable metabolic stability and pharmacokinetic profile (Cmax and AUC), and do not obviously affect heart rate or mean blood pressure when administered intravenously (3 mg/kg) to anesthetized rats.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: β3 AR agonist 1 | β3AR agonist 1 | β3-AR agonist 1 | b3-AR agonist 1 | beta3-AR agonist 1
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