化合物 T10529 T10529
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Product IntroductionBioactivity英文名: BF-168描述: BF-168 is a candidate probe for PET and specifically recognizes both neurit
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Product Introduction
Bioactivity
英文名: BF-168
描述: BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).
体外活性: BF-168 is a potent agent that selectively recognizes SPs and NFTs in AD brain. BF-168 is a candidate probe for PET and is found to specifically recognize both neuritic and diffuse plaques.
体内活性: Intravenous injection of BF-168 in PS1/APP and APP23 transgenic mice results in specific in vivo labeling to both compact and diffuse amyloid deposits in the brain. In addition, 18F-radiolabeled BF-168 demonstrates abundant initial brain uptake (3.9% injected dose/gm at 2 min after injection) and fast clearance (t1/2=24.7 min) after intravenous administration in normal mice.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: BF168 | BF 168 | BF-168
Bioactivity
英文名: BF-168
描述: BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).
体外活性: BF-168 is a potent agent that selectively recognizes SPs and NFTs in AD brain. BF-168 is a candidate probe for PET and is found to specifically recognize both neuritic and diffuse plaques.
体内活性: Intravenous injection of BF-168 in PS1/APP and APP23 transgenic mice results in specific in vivo labeling to both compact and diffuse amyloid deposits in the brain. In addition, 18F-radiolabeled BF-168 demonstrates abundant initial brain uptake (3.9% injected dose/gm at 2 min after injection) and fast clearance (t1/2=24.7 min) after intravenous administration in normal mice.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: BF168 | BF 168 | BF-168
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