Product Introduction
Bioactivity


英文名: BR102375

描述: BR102375 is a non-TZD PPAR γ full agonist (EC50: 0.28 μM) for the treatment of type 2 diabetes.

体外活性: BR102375 (Compound 18) (10 μM) increases gene expression levels relevant to PPARγ activation and enhances glucose uptake under insulin stimulation. BR102375 (10 nM, 100 nM, 1 μM; 6 days, 14 days) shows a concentration-dependent, insulin-sensitive effects on adipogenesis [1].

体内活性: BR102375 has decent efficacy on the mouse diabetes model.BR102375 reveals significant suppressive effect on random blood glucose increase(75 mpk, p.o., bid), shows a decent effect on insulin resistance on the Oral glucose tolerance test (OGTT), and discloses similar findings in body weight gain almost identical to Pioglitazone [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: BR 102375 | BR102375 | BR-102375